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KMID : 1007520140230041267
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Food Science and Biotechnology
2014 Volume.23 No. 4 p.1267 ~ p.1272
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Korean Red Ginseng Extract Alleviates Atherosclerotic Lesions in Apolipoprotein E Knockout Mice
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Jeong Eui-Suk
Seo Jin-Hee
Yoo Ran-Ji
Lee Yong-Jin
Kang Joo-Hyun
Nah Seung-Yeol
Choi Yang-Kyu
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Abstract
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This study was to evaluate the anti-atherosclerotic effect of Korean red ginseng (KRG) in apolipoprotein E knockout (ApoE KO) mice. Female ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 21 weeks. The body weight increased gradually in both the KRG extract inoculation group and the control group inoculated with saline. Plaque lesion areas in the aortic sinus were reduced largely in the KRG inoculation group than in the control group. Triglyceride and inflammatory cytokines such as monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF- α) were significantly reduced in the KRG inoculation group. Additionally, the KRG inoculation group showed significantly lower cardiovascular inflammation by 18Ffluoro- 2-deoxy-D-glucose positron emission tomography/ computed tomography compared to that in the control group. Taken together, KRG alleviates atherosclerotic lesions through MCP-1 and TNF-α suppression. These results suggest that KRG could be a valuable therapeutic strategy for the treatment of atherosclerosis.
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KEYWORD
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Korean red ginseng, apolipoprotein E knockout, atherosclerosis, inflammation, therapeutic strategy
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